Gerald Edward Archer, PhD

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Assistant Professor of Surgery
Assistant Professor of Pathology
Department / Division:
Surgery / Neurosurgery
Address:
208 Sands
Durham, NC 27710
Office Telephone:
(919) 684-6977
Training:
  • PhD, University of Cincinnati, 1988
Research Interests:
My current research focus involves the delivery of therapeutic agents for the treatment of central nervous system neoplasia. Utilizing athymic rat models of central nervous system neoplasia I am investigating compartmental approaches to increase therapeutic efficacy of chemotherapeutic agents and immunoconjugates. Preclinical testing in athymic rats of intrathecal administration of melphalan and 4-hydroperoxycyclophosphamide have resulted in the FDA granting investigational new drug protocols for the treatment of neoplastic meningitis using these two agents. I am also currently involved with the selective intraarterial administration of alkylator resistance modulators to treat intraparechymal brain tumors which are resistant to conventional alkylator therapy. I am also working in collaboration with Dr. Darell Bigner on the characterization of MAbs that react with the epidermal growth factor receptor variant III mutant, a tumor specific antigen.
Representative Publications:
  • Heimberger, AB; Archer, GE; Crotty, LE; McLendon, RE; Friedman, AH; Friedman, HS; Bigner, DD; Sampson, JH. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002;50:158-164.  Abstract
  • Heimberger, AB; Learn, CA; Archer, GE; McLendon, RE; Chewning, TA; Tuck, FL; Pracyk, JB; Friedman, AH; Friedman, HS; Bigner, DD; Sampson, JH. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). Clinical Cancer Research. 2002;8:3496-3502.  Abstract
  • Lal, A; Glazer, CA; Martinson, HM; Friedman, HS; Archer, GE; Sampson, JH; Riggins, GJ. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Research. 2002;62:3335-3339.  Abstract
  • Wildsmith, SE; Archer, GE; Winkley, AJ; Lane, PW; Bugelski, PJ. Maximization of signal derived from cDNA microarrays. BioTechniques: the journal of laboratory technology for bioresearch. 2001;30:202-208.  Abstract
  • Heimberger, AB; Archer, GE; McLendon, RE; Hulette, C; Friedman, AH; Friedman, HS; Bigner, DD; Sampson, JH. Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats. Clinical Cancer Research. 2000;6:4148-4153.  Abstract
  • Heimberger, AB; Crotty, LE; Archer, GE; McLendon, RE; Friedman, A; Dranoff, G; Bigner, DD; Sampson, JH. Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. Journal of Neuroimmunology. 2000;103:16-25.  Abstract
  • Sampson, JH; Crotty, LE; Lee, S; Archer, GE; Ashley, DM; Wikstrand, CJ; Hale, LP; Small, C; Dranoff, G; Friedman, AH; Friedman, HS; Bigner, DD. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proceedings of the National Academy of Sciences of USA. 2000;97:7503-7508.  Abstract