Our Molecular Neuro-Oncology laboratory is an active member of the world-renown Preston Robert Tisch Brain Tumor Center at Duke, as well as the Duke Clinical Research Institute.
Our Molecular Neuro-Oncology laboratory is interested in exploring genomic and proteomic alterations in brain tumorigenesis, as well as their prognostic and therapeutic significance. We use a myriad of in vitro and in vivo models to better characterize important pathways that may be genetically or pharmacologically targeted in order to design future therapeutic approaches. Past projects have focused on exploring specific oncogenes and migration-related genes, epigenetic regulation of gene expression, and protein association studies in malignant brain tumors. Our current laboratory effort has four primary research projects: 1) defining protein associations and signaling networks that underlie specific tumor cell characteristics including glioma cell migration, cytoskeletal rearrangements, extracellular matrix interactions, metabolism, and glioma stem cells; 2) evaluating ways to more specifically target glioma cells with fluorescent probes that may aid in surgical resections; 3) comparing genomic and proteomic signatures between Western and African society meningiomas to better understand the differences in these patient populations; and 4) utilizing local institutional and large national clinical databases to better characterize various brain tumor patients and responses to treatments.
Cory Adamson, MD, PhD, MPH, MHSc, FAANS, FACS
Associate Professor of Surgery (Neurobiology)
Associate Professor in Neurobiology
Medical Science Research Building I
10 Research Drive
DUMC Box 2624
Durham, NC 27710